Article
Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial.
Journal of the American Society of Nephrology : JASN - 1 Jun 2015
Kopp Jeffrey B, Winkler Cheryl A, Zhao Xiongce, Radeva Milena K, Gassman Jennifer J, D'Agati Vivette D, Nast Cynthia C, Wei Changli, Reiser Jochen, Guay-Woodford Lisa M, Pollak Martin R, Hildebrandt Friedhelm, Moxey-Mims Marva, Gipson Debbie S, Trachtman Howard, Friedman Aaron L, Kaskel Frederick J
Abstract excerpt
Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial involved 138 children and young adults who were randomized to cyclosporin or mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome of proteinuria remission. DNA was available from 94 subjects who were genotyped for...
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