Article
APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis.
Pediatric nephrology (Berlin, Germany) - 1 Sept 2021
Zee Jarcy, McNulty Michelle T, Hodgin Jeffrey B, Zhdanova Olga, Hingorani Sangeeta, Jefferson Jonathan Ashley, Gibson Keisha L, Trachtman Howard, Fornoni Alessia, Dell Katherine M, Reich Heather N, Bagnasco Serena, Greenbaum Larry A, Lafayette Richard A, Gipson Debbie S, Brown Elizabeth, Kretzler Matthias, Appel Gerald, Sambandam Kamalanathan K, Tuttle Katherine R, Chen Dhruti, Atkinson Meredith A, Hogan Marie C, Kaskel Frederick J, Meyers Kevin E, O'Toole John, Srivastava Tarak, Sethna Christine B, Hladunewich Michelle A, Lin J J, Nast Cynthia C, Derebail Vimal K, Patel Jiten, Vento Suzanne, Holzman Lawrence B, Athavale Ambarish M, Adler Sharon G, Lemley Kevin V, Lieske John C, Hogan Jonathan J, Gadegbeku Crystal A, Fervenza Fernando C, Wang Chia-Shi, Matar Raed Bou, Singer Pamela, Kopp Jeffrey B, Barisoni Laura, Sampson Matthew G
Abstract excerpt
BACKGROUND: The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). The molecular mechanisms linking APOL1 risk variants with FSGS are not clearly understood, and APOL1's natural absence in laboratory animals makes studying its pathobiology challenging. METHODS: In a cohort of 90 Black patients with...
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