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Article

Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2015

Ruan Cheng-Chao, Ge Qian, Li Yan, Li Xiao-Dong, Chen Dong-Rui, Ji Kai-Da, Wu Yong-Jie, Sheng Li-Juan, Yan Chen, Zhu Ding-Liang, Gao Ping-Jin

Abstract excerpt

OBJECTIVE: We have previously shown an increased expression of complement 3 (C3) in the perivascular adipose tissue (PVAT) in the deoxycorticosterone acetate (DOCA)-salt hypertensive model. This study aims to examine the role and underlying mechanism of C3 in PVAT for understanding the pathogenesis of hypertensive vascular remodeling further. APPROACH AND RESULTS: The role of C3 in macrophage polarization was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25573852
DOI: 10.1161/ATVBAHA.114.304927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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