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Article

Macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins are modulated by complement protein C1q.

Atherosclerosis - 1 Oct 2016

Ho Minh-Minh, Manughian-Peter Ayla, Spivia Weston R, Taylor Adam, Fraser Deborah A

Abstract excerpt

BACKGROUND AND AIMS: This study investigated the effect of innate immune protein C1q on macrophage programmed responses during the ingestion of atherogenic lipoproteins. C1q plays a dual role in atherosclerosis where activation of complement by C1q is known to drive inflammation and promote disease progression. However, C1q is atheroprotective in early disease using mouse models. Our previous studies have...

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Identifiers

PMID: 27573737
DOI: 10.1016/j.atherosclerosis.2016.08.019
PMCID: PMC5064879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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