Article
The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice.
Genes and immunity - 1 Jan 2000
Tokuda S, Do Valle T Z, Batista L, Simon-Chazottes D, Guillemot L, Bouloy M, Flamand M, Montagutelli X, Panthier J-J
Abstract excerpt
The large variation in individual response to infection with Rift Valley fever virus (RVFV) suggests that host genetic determinants play a role in determining virus-induced disease outcomes. These genetic factors are still unknown. The systemic inoculation of mice with RVFV reproduces major pathological features of severe human disease, notably the hepatitis and encephalitis. A genome scan performed on 546...
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