Article

Genetic dissection of Rift Valley fever pathogenesis: <i>Rfvs2</i> on mouse chromosome 11 enables survival to acute-onset hepatitis

2019-02-08

Abstract excerpt

The systemic inoculation of mice with Rift Valley fever virus (RVFV) reproduces major pathological features of severe human disease, notably the acute-onset hepatitis and delayed-onset encephalitis. We previously reported that a genomic interval (Rvfs2) derived from the susceptible MBT/Pas strain is associated with reduced survival time after RVFV infection. In this study, we investigated the pathophysiological m...

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Literature Corpus work: e12e1cf2-51ac-5a6f-aaec-34ac1aa0780d
DOI: 10.1101/545129

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