Article
Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors.
Genes and immunity - 1 Jan 2013
Chevallier L, Blanchet C, Jaubert J, Pachulec E, Demeure C, Carniel E, Panthier J-J, Montagutelli X
Abstract excerpt
We have previously described SEG/Pas as the first mouse inbred strain able to survive subcutaneous injection of virulent Yersinia pestis, the agent of plague, and we identified Yprl1, Yprl2 and Yprl3 as three quantitative trait loci (QTLs) controlling this exceptional phenotype in females from a backcross between SEG/Pas and C57BL/6 strains. We have now developed congenic strains to further characterize the...
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