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Gestational Glucocorticoids' Exposure Impairs Vascular Contractility in Male Offspring Mice With Transgenerational Effects.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2026

Lei Jiahui, Zhao Meng, Yao Shuran, Lu Muxue, Deng Fengying, Xu Ting, Zhang Meihua, Sun Miao, Gao Qinqin

Abstract excerpt

BACKGROUND: The application or excessive exposure to glucocorticoids constitutes a common adverse factor endured by intrauterine fetuses. Gestational glucocorticoids' exposure is intimately associated with the risk of postnatal vascular problems; however, whether the vascular problem can be transgenerationally inherited remains indistinct. In this study, a mouse model of gestational glucocorticoids' exposure was...

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PMID: 41376593
DOI: 10.1161/ATVBAHA.125.323061

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F3
F2

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