Article
The interactions between alcohol consumption and DNA methylation of the ADD1 gene promoter modulate essential hypertension susceptibility in a population-based, case-control study.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Apr 2015
Han Liyuan, Liu Panpan, Wang Changyi, Zhong Qilong, Fan Rui, Wang Lin, Duan Shiwei, Zhang Lina
Abstract excerpt
The potential effects of the interactions between DNA methylation (CpG1 and CpG2-5 methylation levels) of the α-adducin (ADD1) gene promoter and ADD1 tagSNPs (tag single-nucleotide polymorphisms) or the environmental factors on essential hypertension (EH) risk have not been clarified. Thus, we performed an age- and gender-matched case-control study to investigate the association between ADD1 tagSNPs and EH. A...
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