Article
Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations.
Herz - 1 Apr 2015
Zhang S-Y, Chan S-W, Zhou X, Chen X-L, Mok D K W, Lin Z-X, Wang Y-H
Abstract excerpt
BACKGROUND: Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is an enzyme that oxidizes acetaldehyde into acetic acid during alcohol metabolism. Many studies indicate that the rs671 GG genotype in the ALDH2 gene may play a critical role in increasing the risk of essential hypertension (EH) associated with alcohol consumption, which predominantly occurs in men. However, the literature is inconclusive in this regard....
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