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Article

Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp.

The Journal of biological chemistry - 20 Feb 2015

Nakayama Masaaki, Inoue Tetsuyoshi, Naito Mariko, Nakayama Koji, Ohara Naoya

Abstract excerpt

Porphyromonas gingivalis is a major pathogen of periodontal diseases, including periodontitis. We have investigated the effect of P. gingivalis infection on the PI3K/Akt (protein kinase B) signaling pathway in gingival epithelial cells. Here, we found that live P. gingivalis, but not heat-killed...

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Source

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Identifiers

PMID: 25564612
DOI: 10.1074/jbc.M114.591610
PMCID: PMC4335252

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25564612-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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