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Article

Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Glowczyk Izabela, Wong Alicia, Potempa Barbara, Babyak Olena, Lech Maciej, Lamont Richard J, Potempa Jan, Koziel Joanna

Abstract excerpt

Gingipain cysteine proteases are considered key virulence factors of Porphyromonas gingivalis. They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks. Recent data indicate the role of P. gingivalis in T cell differentiation; however, the involvement of gingipains in this process remains elusive. Therefore, the aim of this...

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Identifiers

PMID: 28497028
DOI: 10.3389/fcimb.2017.00140
PMCID: PMC5406403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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