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Article

Porphyromonas gingivalis triggers NLRP3‐mediated inflammasome activation in macrophages in a bacterial gingipains‐independent manner

3 Oct 2018

Abstract excerpt

Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that has been considered to be one of the bacteria associated with progression of human periodontitis. Subgingival biofilms formed by bacteria, including P. gingivalis, induce chronic inflammation, and activation of inflammasome in the gingival tissue. However, the mechanisms of P. gingivalis-triggering inflammasome activation and the role of...

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PMID: 30280383
DOI: 10.1002/eji.201847658

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