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Article

Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II.

The Journal of biological chemistry - 13 Feb 2015

Noor Sina Ibne, Dietz Steffen, Heidtmann Hella, Boone Christopher D, McKenna Robert, Deitmer Joachim W, Becker Holger M

Abstract excerpt

Proton-coupled monocarboxylate transporters (MCTs) mediate the exchange of high energy metabolites like lactate between different cells and tissues. We have reported previously that carbonic anhydrase II augments transport activity of MCT1 and MCT4 by a noncatalytic mechanism, while leaving transport activity of MCT2 unaltered. In the present study, we combined electrophysiological measurements in Xenopus oocytes...

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Identifiers

PMID: 25561737
DOI: 10.1074/jbc.M114.624577
PMCID: PMC4326851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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