Article
A diverse range of bacterial and eukaryotic chitinases hydrolyzes the LacNAc (Galβ1-4GlcNAc) and LacdiNAc (GalNAcβ1-4GlcNAc) motifs found on vertebrate and insect cells.
The Journal of biological chemistry - 27 Feb 2015
Frederiksen Rikki F, Yoshimura Yayoi, Storgaard Birgit G, Paspaliari Dafni K, Petersen Bent O, Chen Kowa, Larsen Tanja, Duus Jens Ø, Ingmer Hanne, Bovin Nicolai V, Westerlind Ulrika, Blixt Ola, Palcic Monica M, Leisner Jørgen J
Abstract excerpt
There is emerging evidence that chitinases have additional functions beyond degrading environmental chitin, such as involvement in innate and acquired immune responses, tissue remodeling, fibrosis, and serving as virulence factors of bacterial pathogens. We have recently shown that both the human chitotriosidase and a chitinase from Salmonella enterica serovar Typhimurium hydrolyze LacNAc from...
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