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Structure and functional analysis of the <i>Legionella</i> chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation

2019-07-02

Abstract excerpt

Chitinases are important enzymes that contribute to the generation of carbon and nitrogen from chitin, a long chain polymer of N-acetylglucosamine that is abundant in insects, fungi, invertebrates and fish. Although mammals do not produce chitin, chitinases have been identified in bacteria that are key virulence factors in severe respiratory, gastrointestinal and urinary diseases. However, it is unclear how these...

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Literature Corpus work
b6a85e03-fe35-5eb8-b0ca-aeb526414256
DOI
10.1101/687871
Open publication

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