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Article

Exploring roles of the chitinase ChiC in modulating Pseudomonas aeruginosa virulence phenotypes.

Microbiology spectrum - 2 Jul 2024

Edvardsen Per Kristian Thorén, Askarian Fatemeh, Zurich Raymond, Nizet Victor, Vaaje-Kolstad Gustav

Abstract excerpt

Chitinases are ubiquitous enzymes involved in biomass degradation and chitin turnover in nature. Pseudomonas aeruginosa (PA), an opportunistic human pathogen, expresses ChiC, a secreted glycoside hydrolase 18 family chitinase. Despite speculation about ChiC's role in PA disease pathogenesis, there is scant evidence supporting this hypothesis. Since PA cannot catabolize chitin, we investigated the potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38819151
DOI: 10.1128/spectrum.00546-24
PMCID: PMC11218509

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