Article
Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis.
Photodermatology, photoimmunology & photomedicine - 1 Mar 2015
Romaní Jorge, Julià Marc, Lozano Francisco, Muñoz-Santos Carlos, Guilabert Antonio, Carrascosa José M, Rigla Mercedes, Luelmo Jesús
Abstract excerpt
BACKGROUND: Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll-like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy....
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