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Article

Association between Psoriasis Disease and IFN-λ Gene Polymorphisms.

Immunological investigations - 1 Aug 2022

Yilmaz Büşra, Çakmak Genç Güneş, Karakaş Çelik Sevim, Solak Tekin Nilgün, Can Murat, Dursun Ahmet

Abstract excerpt

Psoriasis is one of the most common chronic immune-mediated skin diseases, having a strong genetic predisposition. Psoriasis is a T-cell-mediated disease with a mixed Th1/Th17 cytokines environment. IL-23/IL-17 axis hyperactivation is the primary pathogenesis. Psoriasis lesions have been known to exhibit high IFN-λ1 and IFN-stimulated genes (ISGs) expression, which appears to be driven by Th17 cells. However, the...

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PMID: 35118914
DOI: 10.1080/08820139.2022.2036187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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