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Article

TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells.

Pflugers Archiv : European journal of physiology - 1 Oct 2015

Mrkonjić Sanela, Garcia-Elias Anna, Pardo-Pastor Carlos, Bazellières Elsa, Trepat Xavier, Vriens Joris, Ghosh Debapriya, Voets Thomas, Vicente Rubén, Valverde Miguel A

Abstract excerpt

Calcium signaling participates in different cellular processes leading to cell migration. TRPV4, a non-selective cation channel that responds to mechano-osmotic stimulation and heat, is also involved in cell migration. However, the mechanistic involvement of TRPV4 in cell migration is currently unknown. We now report that expression of the mutant channel TRPV4-(121)AAWAA (lacking the phosphoinositide-binding site...

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Source

Identifiers

PMID: 25559845
DOI: 10.1007/s00424-014-1679-8

Genes

TRPV4
TRPC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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