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Article

Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes.

PloS one - 30 Nov 2010

Svensson Lena, McDowall Alison, Giles Katherine M, Stanley Paula, Feske Stefan, Hogg Nancy

Abstract excerpt

The immune cells named T lymphocytes circulate around the body fulfilling their role in immunosurveillance by monitoring the tissues for injury or infection. To migrate from the blood into the tissues, they make use of the integrin LFA-1 which is exclusively expressed by immune cells. These highl...

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Source

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Identifiers

PMID: 21152086
DOI: 10.1371/journal.pone.0015090
PMCID: PMC2994845

Genes

BOC
ORAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21152086-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes.PMID 21152086Read ↗

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Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program.Semantic proximity Read ↗

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.Semantic proximity Read ↗

Orai1 function is essential for T cell homing to lymph nodes.Semantic proximity Read ↗

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and ActivationSemantic proximity Read ↗

RNAi Library Screening Reveals Gβ 1 , Casein Kinase 2α and ICAP-1 as Novel Regulators of LFA-1-mediated T-cell Polarity and MigrationSemantic proximity Read ↗

Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active.Semantic proximity Read ↗

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