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Disease‐related mutations among Caribbean Hispanics with familial dementia

4 Jun 2014

Abstract excerpt

Pathogenic mutations in the three known genes - the amyloid precursor protein (APP), presenilin 1 (PSEN1), presenilin 2 (PSEN2) - are known to cause familial Alzheimer's disease (AD) and tend to be associated with early-onset AD. However, the frequency and risk associated with these mutations vary widely. In addition, mutations in the frontotemporal lobar degeneration (FTLD) genes - the microtubule-associated...

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PMID: 25333068
DOI: 10.1002/mgg3.85

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