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Article

HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation

3 Jan 2015

Abstract excerpt

Chromosomal instability is a hallmark of human cancers and is closely linked to tumorigenesis. The prognostic value of molecular signatures of chromosomal instability (CIN) has been validated in various cancers. However, few studies have examined the relationship between CIN and glioma. Histone deacetylases (HDACs) regulate chromosome structure and are linked to the loss of genomic integrity in cancer cells. In...

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Share to Epigenetics and DNA Methylation
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PMID: 25557107
DOI: 10.1007/s11060-014-1709-6

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