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Article

Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells

13 Mar 2017

Abstract excerpt

Overexpression of structural maintenance of chromosomes 4 (SMC4) has been reported to be involved in tumor cell growth, migration and invasion, and to be correlated with poor prognosis of cancer patient. However, its clinical significance and biological role in glioma remain unknown. Herein, we found that SMC4 expression at both mRNA and protein level was markedly increased in glioma cells and clinical tissues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28287612
DOI: 10.1038/oncsis.2017.8

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