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Article

Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1.

Journal of molecular biology - 27 Feb 2015

Singh Mahavir, Wang Zhonghua, Cascio Duilio, Feigon Juli

Abstract excerpt

Shq1 is an essential protein involved in the early steps of biogenesis and assembly of H/ACA ribonucleoprotein particles (RNPs). Shq1 binds to dyskerin (Cbf5 in yeast) at an early step of H/ACA RNP assembly and is subsequently displaced by the H/ACA RNA. Shq1 contains an N-terminal CS and a C-terminal Shq1-specific domain (SSD). Dyskerin harbors many mutations associated with dyskeratosis congenita. Structures of...

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Identifiers

PMID: 25553844
DOI: 10.1016/j.jmb.2014.12.012
PMCID: PMC4323627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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