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Article

RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair.

EMBO reports - 1 Nov 2009

Wang Jingxin, Jacob Naduparambil K, Ladner Katherine J, Beg Amer, Perko James D, Tanner Stephan M, Liyanarachchi Sandya, Fishel Richard, Guttridge Denis C

Abstract excerpt

Nuclear factor (NF)-kappaB is a positive regulator of tumour development and progression, but how it functions in normal cells leading to oncogenesis is not clear. As cellular senescence has proven to be an intrinsic tumour suppressor mechanism that cells must overcome to establish deregulated growth, we used primary fibroblasts to follow NF-kappaB function in cells transitioning from senescence to subsequent...

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Identifiers

PMID: 19779484
DOI: 10.1038/embor.2009.197
PMCID: PMC2775178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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