Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of the SETBP1 gene and splicing pathway genes SF3B1, U2AF1, and SRSF2 in childhood acute myeloid leukemia.

Annals of laboratory medicine - 1 Jan 2015

Choi Hyun-Woo, Kim Hye-Ran, Baek Hee-Jo, Kook Hoon, Cho Duck, Shin Jong-Hee, Suh Soon-Pal, Ryang Dong-Wook, Shin Myung-Geun

Abstract excerpt

BACKGROUND: Recurrent somatic SET-binding protein 1 (SETBP1) and splicing pathway gene mutations have recently been found in atypical chronic myeloid leukemia and other hematologic malignancies. These mutations have been comprehensively analyzed in adult AML, but not in childhood AML. We investigated possible alteration of the SETBP1, splicing factor 3B subunit 1 (SF3B1), U2 small nuclear RNA auxiliary factor 1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytogenetic Analysis
Share to Phosphoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoprotein, U2 Small Nuclear

Share to Ribonucleoproteins

Share to RNA Splicing

Share to RNA Splicing Factors

Share to Serine-Arginine Splicing Factors

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 25553291
DOI: 10.3343/alm.2015.35.1.118
PMCID: PMC4272941

Genes

SETBP1
SRSF2
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of the SETBP1 gene and splicing pathway genes SF3B1, U2AF1, and SRSF2 in childhood acute myeloid leukemia.PMID 25553291Read ↗

Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.Semantic proximity Read ↗

Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.Semantic proximity Read ↗

Somatic Mutations in Schinzel-Giedion Syndrome Gene SETBP1 Determine Progression in Myeloid MalignanciesSemantic proximity Read ↗

Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors.Semantic proximity Read ↗

Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemiaSemantic proximity Read ↗

Clinical presentation and differential splicing of<i>SRSF2, U2AF1</i>and<i>SF3B1</i>mutations in patients with Acute Myeloid LeukaemiaSemantic proximity Read ↗

Aberrant expression of splicing factors in newly diagnosed acute myeloid leukemia.Semantic proximity Read ↗

SETBP1 is dispensable for normal and malignant hematopoiesis.Semantic proximity Read ↗

The impact of SETBP1 mutations in neurological diseases and cancer.Semantic proximity Read ↗

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML.Semantic proximity Read ↗

Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia.Semantic proximity Read ↗

Evaluation of a father and son with atypical chronic myeloid leukemia with SETBP1 mutations and a review of the literature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.