Article
Evaluation of a father and son with atypical chronic myeloid leukemia with SETBP1 mutations and a review of the literature.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jul 2015
Wang L, Du F, Zhang H-M, Wang H-X
Abstract excerpt
We report the case of a father and son diagnosed with atypical chronic myeloid leukemia (aCML). Both patients harbored SETBP1 mutations, which are present in 24.3% of aCML patients. Moreover, both shared the variant encoding p.Pro737His, but the aCML severity was greater in the son because of the presence of two other missense mutations causing p.Asp868Asn and p.Ser885Arg alterations. SETBP1 mutations may be...
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