Article
Quantitative detection of circulating nucleophosmin mutations DNA in the plasma of patients with acute myeloid leukemia.
International journal of medical sciences - 1 Jan 2015
Quan Jing, Gao Yu-jie, Yang Zai-lin, Chen Hui, Xian Jing-rong, Zhang Shuai-shuai, Zou Qin, Zhang Ling
Abstract excerpt
OBJECTIVE: The aim of this study was to quantify the copies of circulating nucleophosmin (NPM) mutations DNA in the plasma of patients with acute myeloid leukemia (AML) and to explore the association of circulating NPM mutation levels with clinical characteristics. DESIGN AND METHODS: The presence of NPM mutations in 100 Chinese patients newly diagnosed with AML were identified by RT-PCR and sequencing analysis....
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