Article
Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.
American journal of physiology. Heart and circulatory physiology - 1 Dec 2020
Cheng Tik-Chee, Philip Jennifer L, Tabima Diana M, Kumari Santosh, Yakubov Bakhtiyor, Frump Andrea L, Hacker Timothy A, Bellofiore Alessandro, Li Rongbo, Sun Xin, Goss Kara N, Lahm Tim, Chesler Naomi C
Abstract excerpt
Although women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been identified as a likely mediator for estrogen protection in the RV. However, the role of ERα in preserving RV function and remodeling during pressure overload remains poorly understood. We hypothesized that loss of functional ERα...
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