Article
Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line.
Metabolism: clinical and experimental - 1 Apr 2016
Saito Kenji, He Yanlin, Yan Xiaofeng, Yang Yongjie, Wang Chunmei, Xu Pingwen, Hinton Antentor Othrell, Shu Gang, Yu Likai, Tong Qingchun, Xu Yong
Abstract excerpt
BACKGROUND: A variety of biological functions of estrogens, including regulation of energy metabolism, are mediated by neurons expressing estrogen receptor-α (ERα) in the brain. However, complex intracellular processes in these ERα-expressing neurons are difficult to unravel, due to the lack of strategy to visualize ERα-expressing neurons, especially in unfixed brain tissues. RESULTS AND CONCLUSIONS: Here we...
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