Article

Tissue Distribution and Quantitative Analysis of Estrogen Receptor- (ER ) and Estrogen Receptor- (ER ) Messenger Ribonucleic Acid in the Wild-Type and ER -Knockout Mouse

1997-11-01

Abstract excerpt

Until recently, only a single type of estrogen receptor (ER) was thought to exist and mediate the genomic effects of the hormone 17β-estradiol in mammalian tissues. However, the cloning of a gene encoding a second type of ER, termed ERβ, from the mouse, rat, and human has prompted a reevaluation of the estrogen signaling system. Based on in vitro studies, the ERβ protein binds estradiol with an affinity similar to...

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Literature Corpus work: 1ea1c754-8c69-531c-a533-d424363e84e1
DOI: 10.1210/en.138.11.4613

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