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Article

Robust Prediction of Resistance to Trimethoprim in Staphylococcus aureus.

Cell chemical biology - 15 Mar 2018

Fowler Philip W, Cole Kevin, Gordon N Claire, Kearns Angela M, Llewelyn Martin J, Peto Tim E A, Crook Derrick W, Walker A Sarah

Abstract excerpt

The rise of antibiotic resistance threatens modern medicine; to combat it new diagnostic methods are required. Sequencing the whole genome of a pathogen offers the potential to accurately determine which antibiotics will be effective to treat a patient. A key limitation of this approach is that it cannot classify rare or previously unseen mutations. Here we demonstrate that alchemical free energy methods, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29307840
DOI: 10.1016/j.chembiol.2017.12.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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