Article
Influence of growth hormone receptor (GHR) exon 3 and -202A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly.
Pituitary - 1 Oct 2015
Jallad Raquel S, Trarbach Ericka B, Duarte Felipe H, Jorge Alexander A L, Bronstein Marcello D
Abstract excerpt
BACKGROUND: The association of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms with clinical presentation, biochemical measurements and response to therapies in acromegaly have been suggested. OBJECTIVE: To evaluate the presence of these polymorphisms in acromegaly and their influence on clinical and laboratorial characteristics of patients at diagnosis and after treatment in a large cohort of acromegalic patients....
Topics
- Acromegaly
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
- Brazil
- Carrier Proteins
- Cross-Sectional Studies
- Exons
- Female
- Genetic Predisposition to Disease
- Human Growth Hormone
- Humans
- Insulin-Like Growth Factor Binding Protein 3