Article
Clinical and biochemical impact of the d3 growth hormone receptor genotype in acromegaly.
The Journal of clinical endocrinology and metabolism - 1 Sept 2008
Mercado Moisés, González Baldomero, Sandoval Carolina, Esquenazi Yoshua, Mier Fernando, Vargas Guadalupe, de los Monteros Ana Laura Espinosa, Sosa Ernesto
Abstract excerpt
CONTEXT: Lack of exon 3 of the GH receptor (d3-GHR) has been associated with increased responsiveness to GH therapy. By analogy, we hypothesized that patients with acromegaly bearing the d3-GHR genotype may have a more morbid clinical and biochemical picture. OBJECTIVE: Our objective was to deter...
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