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Article

d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.

Clinical endocrinology - 1 May 2010

Montefusco Laura, Filopanti Marcello, Ronchi Cristina L, Olgiati Luca, La-Porta Carmen, Losa Marco, Epaminonda Paolo, Coletti Francesca, Beck-Peccoz Paolo, Spada Anna, Lania Andrea G, Arosio Maura

Abstract excerpt

OBJECTIVE: A common polymorphic variant of the growth hormone receptor (GHR) is because of genomic deletion of exon 3 and has been linked with increased responsiveness to exogenous GH. The impact of this polymorphism in acromegaly, a disease characterized by endogenous excess of GH and partial loss of IGF-I feedback on tumoural GH secretion, is not clear. The aim of this study was to investigate possible...

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Source

Identifiers

PMID: 20447065
DOI: 10.1111/j.1365-2265.2009.03703.x

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.PMID 20447065Read ↗

The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly.Semantic proximity Read ↗

Clinical and biochemical impact of the d3 growth hormone receptor genotype in acromegaly.Semantic proximity Read ↗

Growth hormone (GH) receptor isoform in acromegaly: lower concentrations of GH but not insulin-like growth factor-1 in patients with a genomic deletion of exon 3 in the GH receptor gene.Semantic proximity Read ↗

D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly.Semantic proximity Read ↗

Influence of growth hormone receptor (GHR) exon 3 and -202A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly.Semantic proximity Read ↗

The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly.Semantic proximity Read ↗

The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly.Semantic proximity Read ↗

The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism - a Favorable Backdoor Mechanism for the GHR FunctionSemantic proximity Read ↗

The distribution of exon 3-deleted/full-length growth hormone receptor polymorphism in the Turkish population.Semantic proximity Read ↗

The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.Semantic proximity Read ↗

Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome.Semantic proximity Read ↗

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty.Semantic proximity Read ↗

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