Article
d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.
Clinical endocrinology - 1 May 2010
Montefusco Laura, Filopanti Marcello, Ronchi Cristina L, Olgiati Luca, La-Porta Carmen, Losa Marco, Epaminonda Paolo, Coletti Francesca, Beck-Peccoz Paolo, Spada Anna, Lania Andrea G, Arosio Maura
Abstract excerpt
OBJECTIVE: A common polymorphic variant of the growth hormone receptor (GHR) is because of genomic deletion of exon 3 and has been linked with increased responsiveness to exogenous GH. The impact of this polymorphism in acromegaly, a disease characterized by endogenous excess of GH and partial loss of IGF-I feedback on tumoural GH secretion, is not clear. The aim of this study was to investigate possible...
Topics
- Acromegaly
- Adult
- Body Mass Index
- Body Weight
- Exons
- Female
- Gene Deletion
- Gene Frequency
- Genotype
- Glucose Tolerance Test
- Human Growth Hormone
- Humans
- Insulin-Like Growth Factor I