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Histone Deacetylase Inhibitors Improve <i>In Vitro</i> and <i>In Vivo</i> Developmental Competence of Somatic Cell Nuclear Transfer Porcine Embryos

4 Feb 2010

Abstract excerpt

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It has been demonstrated that the developmental competence of SCNT embryos in several species were significantly enhanced via treatment of histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA) to increase histone acetylation....

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PMID: 20132015
DOI: 10.1089/cell.2009.0038

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