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Zebularine and Scriptaid Significantly Improve Epigenetic Reprogramming of Yak Fibroblasts and Cloning Efficiency

22 Jun 2013

Abstract excerpt

Abnormal epigenetic reprogramming of the donor nucleus after somatic cell nuclear transfer (SCNT) is thought to be the main cause of low cloning efficiency. Following SCNT, the donor nucleus often fails to express early embryonic genes and establish a normal embryonic pattern of chromatin modification. Therefore, in this study, we have attempted to improve epigenetic reprogramming of the donor nucleus and cloned...

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PMID: 23790013
DOI: 10.1089/cell.2012.0092

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