Article
Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2.
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2010
Weller Shaun G, Capitani Mirco, Cao Hong, Micaroni Massimo, Luini Alberto, Sallese Michele, McNiven Mark A
Abstract excerpt
The size and integrity of the Golgi apparatus is maintained via a tightly controlled regulation of membrane traffic using a variety of different signaling and cytoskeletal proteins. We have recently observed that activation of c-Src has profound effects on Golgi structure, leading to dramatically...
Topics
- Amino Acid Substitution
- Animals
- Cell Line, Tumor
- Cells, Cultured
- Cricetinae
- Dynamin II
- Golgi Apparatus
- HeLa Cells
- Humans
- Membrane Glycoproteins
- Mutagenesis, Site-Directed
- Pancreatic Neoplasms
- Phenotype
- Phosphorylation
- RNA, Small Interfering