Article
The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system.
The Journal of biological chemistry - 24 Nov 2006
Mbonye Uri R, Wada Masayuki, Rieke Caroline J, Tang Hui-Yuan, Dewitt David L, Smith William L
Abstract excerpt
Cyclooxygenase (COX) isoforms catalyze the committed step in prostaglandin biosynthesis. The primary structures of COX-1 and COX-2 are very similar except that COX-2 has a 19-amino acid (19-AA) segment of unknown function located just inside its C terminus. Here we provide evidence that the major role of the 19-AA cassette is to mediate entry of COX-2 into the ER-associated degradation system that transports ER...
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