Article
A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015
Tebartz Christina, Horst Sarah Anita, Sparwasser Tim, Huehn Jochen, Beineke Andreas, Peters Georg, Medina Eva
Abstract excerpt
Staphylococcus aureus can cause difficult-to-treat chronic infections. We recently reported that S. aureus chronic infection was associated with a profound inhibition of T cell responses. In this study, we investigated the mechanisms responsible for the suppression of T cell responses during chronic S. aureus infection. Using in vitro coculture systems, as well as in vivo adoptive transfer of CFSE-labeled OT-II...
Topics
- Adoptive Transfer
- Animals
- B-Lymphocytes, Regulatory
- Cell Communication
- Coculture Techniques
- Cytokines
- Dendritic Cells
- Disease Models, Animal
- Female
- Immune Tolerance
- Immunomodulation
- Immunophenotyping
- Mice