Article
Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2012
Kaplan Amber, Ma Jun, Kyme Pierre, Wolf Andrea J, Becker Courtney A, Tseng Ching Wen, Liu George Y, Underhill David M
Abstract excerpt
The importance of type I IFNs in the host response to viral infection is well established; however, their role in bacterial infection is not fully understood. Several bacteria (both Gram-positive and -negative) have been shown to induce IFN-β production in myeloid cells, but this IFN-β is not always beneficial to the host. We examined whether Staphylococcus aureus induces IFN-β from myeloid phagocytes, and if so,...
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