Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.

doi:10.1371/journal.ppat.1010430

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.

PLoS pathogens - 1 Apr 2022

Bartsch Patricia, Kilian Christoph, Hellmig Malte, Paust Hans-Joachim, Borchers Alina, Sivayoganathan Amirrtavarshni, Enk Leon, Zhao Yu, Shaikh Nikhat, Büttner Henning, Wong Milagros N, Puelles Victor G, Wiech Thorsten, Flavell Richard, Huber Tobias B, Turner Jan-Eric, Bonn Stefan, Huber Samuel, Gagliani Nicola, Mittrücker Hans-Willi, Rohde Holger, Panzer Ulf, Krebs Christian F

Abstract excerpt

Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis. In particular, Th1 and Th17 cells secreting IFN-γ and IL-17A, are involved in the control of systemic S. aureus infections in humans and mice. To investigate the role of T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Plasticity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-17

Share to Sepsis

Share to Staphylococcal Infections

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Share to Th1 Cells

Share to Th17 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 35446923
DOI: 10.1371/journal.ppat.1010430
PMCID: PMC9064098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.PMID 35446923Read ↗

Clonal Vγ6 + Vδ4 + T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infectionSemantic proximity Read ↗

Th17 cells in immunity and autoimmunity.Semantic proximity Read ↗

Functional and phenotypic heterogeneity of Th17 cells in health and diseaseSemantic proximity Read ↗

Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infectionSemantic proximity Read ↗

Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureusSemantic proximity Read ↗

Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogensSemantic proximity Read ↗

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against InfectionSemantic proximity Read ↗

Are Th17 cells an appropriate new target in the treatment of rheumatoid arthritis?Semantic proximity Read ↗

MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitisSemantic proximity Read ↗

Spontaneous preputial gland adenitis in <i>Staphylococcus aureus</i> -colonized male C57Bl/6 mice triggers a Th17-driven immune responseSemantic proximity Read ↗

Development and function of interleukin 17-producing γδ T cells.Semantic proximity Read ↗

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.