Islet beta cell failure in type 2 diabetes.

doi:10.1172/JCI29103

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Article

Islet beta cell failure in type 2 diabetes.

The Journal of clinical investigation - 1 Jul 2006

Prentki Marc, Nolan Christopher J

Abstract excerpt

The major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of beta cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of beta cell mass and for enhanced beta cell performance. The...

Topics

Animals
Diabetes Mellitus, Type 2
Disease Progression
Genetic Predisposition to Disease
Humans
Insulin Resistance
Insulin-Secreting Cells

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Identifiers

PMID: 16823478
DOI: 10.1172/JCI29103
PMCID: PMC1483155

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