Article
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
PLoS genetics - 10 Feb 2011
Lettre Guillaume, Palmer Cameron D, Young Taylor, Ejebe Kenechi G, Allayee Hooman, Benjamin Emelia J, Bennett Franklyn, Bowden Donald W, Chakravarti Aravinda, Dreisbach Al, Farlow Deborah N, Folsom Aaron R, Fornage Myriam, Forrester Terrence, Fox Ervin, Haiman Christopher A, Hartiala Jaana, Harris Tamara B, Hazen Stanley L, Heckbert Susan R, Henderson Brian E, Hirschhorn Joel N, Keating Brendan J, Kritchevsky Stephen B, Larkin Emma, Li Mingyao, Rudock Megan E, McKenzie Colin A, Meigs James B, Meng Yang A, Mosley Tom H, Newman Anne B, Newton-Cheh Christopher H, Paltoo Dina N, Papanicolaou George J, Patterson Nick, Post Wendy S, Psaty Bruce M, Qasim Atif N, Qu Liming, Rader Daniel J, Redline Susan, Reilly Muredach P, Reiner Alexander P, Rich Stephen S, Rotter Jerome I, Liu Yongmei, Shrader Peter, Siscovick David S, Tang W H Wilson, Taylor Herman A, Tracy Russell P, Vasan Ramachandran S, Waters Kevin M, Wilks Rainford, Wilson James G, Fabsitz Richard R, Gabriel Stacey B, Kathiresan Sekar, Boerwinkle Eric
Abstract excerpt
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) in individuals of African ancestry, we performed a genome-wide association study (GWAS) in 8,090 African Americans from five population-based cohorts. We...
Read the complete abstract on PubMed