Article
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
Circulation. Cardiovascular genetics - 1 Jun 2010
Smith Nicholas L, Felix Janine F, Morrison Alanna C, Demissie Serkalem, Glazer Nicole L, Loehr Laura R, Cupples L Adrienne, Dehghan Abbas, Lumley Thomas, Rosamond Wayne D, Lieb Wolfgang, Rivadeneira Fernando, Bis Joshua C, Folsom Aaron R, Benjamin Emelia, Aulchenko Yurii S, Haritunians Talin, Couper David, Murabito Joanne, Wang Ying A, Stricker Bruno H, Gottdiener John S, Chang Patricia P, Wang Thomas J, Rice Kenneth M, Hofman Albert, Heckbert Susan R, Fox Ervin R, O'Donnell Christopher J, Uitterlinden Andre G, Rotter Jerome I, Willerson James T, Levy Daniel, van Duijn Cornelia M, Psaty Bruce M, Witteman Jacqueline C M, Boerwinkle Eric, Vasan Ramachandran S
Abstract excerpt
BACKGROUND: Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the association of 2,478,304 single-nucleotide polymorphisms with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the...
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