Article
Mechanical stress downregulates MHC class I expression on human cancer cell membrane.
PloS one - 1 Jan 2014
La Rocca Rosanna, Tallerico Rossana, Talib Hassan Almosawy, Das Gobind, Lakshmikanth Tadepally, Tadepally Lakshmikanth, Matteucci Marco, Liberale Carlo, Mesuraca Maria, Scumaci Domenica, Gentile Francesco, Cojoc Gheorghe, Perozziello Gerardo, Ammendolia Antonio, Gallo Adriana, Kärre Klas, Cuda Giovanni, Candeloro Patrizio, Di Fabrizio Enzo, Carbone Ennio
Abstract excerpt
In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound...
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