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Article

Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment.

Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2020

Wang Yong, Goliwas Kayla F, Severino Paige E, Hough Kenneth P, Van Vessem Derek, Wang Hong, Tousif Sultan, Koomullil Roy P, Frost Andra R, Ponnazhagan Selvarangan, Berry Joel L, Deshane Jessy S

Abstract excerpt

Breast cancer (BCa) proliferates within a complex, three-dimensional microenvironment amid heterogeneous biochemical and biophysical cues. Understanding how mechanical forces within the tumor microenvironment (TME) regulate BCa phenotype is of great interest. We demonstrate that mechanical strain enhanced the proliferation and migration of both estrogen receptor+ and triple-negative (TNBC) human and mouse BCa...

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Identifiers

PMID: 32572176
DOI: 10.1038/s41374-020-0452-1
PMCID: PMC7686122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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