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Article

PTPN22 and uterine leiomyomas.

European journal of obstetrics, gynecology, and reproductive biology - 1 Feb 2015

Gloria-Bottini Fulvia, Pietropolli Adalgisa, Ammendola Maria, Saccucci Patrizia, Bottini Egidio

Abstract excerpt

OBJECTIVE: It has been suggested that the development of uterine leiomyomas is positively influenced by an immune system in a chronically inflammatory state and that a lower level of regulating T cell (Treg cells) would play a central role. Since it has been suggested that the W620 variant of protein tyrosine phosphatase non-receptor type 22 (PTPN22) decreases the number of Treg cells, we investigated a possible...

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Topics

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Share to Age Factors
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Share to ACP1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Leiomyoma

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Uterine Neoplasms

Source

Identifiers

PMID: 25541531
DOI: 10.1016/j.ejogrb.2014.11.043

Genes

PTPN22
ACP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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