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Article

Susceptibility Risk Alleles of -238G/A, -308G/A and -1031T/C Promoter Polymorphisms of TNF-α Gene to Uterine Leiomyomas.

Recent advances in DNA & gene sequences - 1 Jan 2015

Medikare Veronica, Ali Altaf, Ananthapur Venkateshwari, Deendayal Mamata, Nallari Pratibha

Abstract excerpt

BACKGROUND: Uterine Leiomyomas (UL) are non-cancerous single celled mass of uterine smooth muscles distinguished by presence of large amounts of collagen, fibronectin and proteoglycans. Tumor necrosis factor-α (TNF-α), an inflammation inducing cytokine, plays a major role in various disorders of the immune system; is involved in tumor development and progression. It is proposed to study the influence of three...

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PMID: 26467281
DOI: 10.2174/2352092210999151214155858

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TNF

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